Nextar pharmaceutical development team offers a wide range of preformulation and formulation development to achieve a successful dosage form development. Formulations are rationally designed and developed to ensure and enhance product stability and meet the specific product specifications defined by the client.
 
Our Formulation labs are fully equipped with all the required modern instrumentation and in silico tools to calculate and determine experimentally all the physicochemical properties of drug candidates. The most appropriate excipients and ingredients are selected in order to be compatible with the drug and to preserve its pharmacological efficacy within the dosage form.
 
Nextar pharmaceutical scientists have vast experience and expertise in formulating poorly water soluble drugs using a range of non-proprietary solubility enhancement techniques and formulation strategies.
 
Our formulation development services include:

• Pre-formulation studies, determination of physicochemical properties using in-silico tools (log P, log D, pKa), particle size distribution, zeta potential.
• Drug solubility in aqueous media and organic solvents.
• Hygroscopicity studies.
• Compatibility studies for excipients and packaging materials.
• Dissolution tests of drug products in simulated gastric and intestinal fluids.
• Formulation development of a wide variety of dosage forms
• injectables, ophthalmic solutions, lyophilized powders, topical creams, ointments, gels, suspensions, emulsions, capsules, tablets.
• Formulation strategies for solubility enhancement and improvement of bioavailability by drug complexation with cyclodextrins or solubilization with surfactants and cosolvents.
• Formulation of slow-release and controlled-release drug delivery systems.
• Drug encapsulation in liposomes and nanoparticles.
• Formulation and production of batches for stability testing.
• Formulation of test articles and preparation for preclinical efficacy, pharmacokinetics and toxicology studies.
• Commercial formulation development